Endocrine Abstracts

Introduction and Objectives: The prevalence of prediabetes in the adult Spanish population is close to 15%. People with prediabetes are not only at high risk of developing T2DM but also at high cardiovascular risk. Several drugs, including metformin, glitazones, GLP-1RAs and SGLT2is have been found to reduce the incidence of diabetes in this population, but none is currently licensed with this indication. In particular α-glucosidase inhibitors such as acarbose have been s...

Introduction and Objective: Extended-release metformin has much better gastrointestinal tolerability than conventional (immediate release)metformin and according to the UK NICE guidelines should be offered to patients who have gastrointestinal tolerance issues with conventional metformin. We rechallenged patients with T2DM labelled as metformin-intolerant and treated with a DPP4i with a single-pill combination (SPC) of extended release metformin and sitagliptin (1000/50 mg) in...

Introduction and Objectives: The tolerability of extended-release metformin (XRM) is clearly superior to that of conventional metformin, with the potential to improve patient compliance, effectiveness and outcomes. Since 2005 the NICE guidelines for type 2 diabetes mellitus (T2DM) recommend its use in patients with metformin-caused gastrointestinal disturbances. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. We assessed the ...

The brain plays a crucial role in maintaining the body’s energy needs, a process involving the activity of a group of hypothalamic neurons that express the neuropeptidergic marker pro-opiomelanocortin (POMC). POMC neuronal dysfunction can cause obesity and its associated metabolic sequelae. However, this population of neurons is highly diverse at a molecular and functional level, and whether or not such heterogeneity is implicated in disease establishment or progression h...

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Since November 2020 the use of this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and December 2021 in patients with DM3c in which FGM implementat...

Introduction and Objectives: Poor metabolic control in Type 1 Diabetes Mellitus (DM 1) is associated with micro and macrovascular complications. The implementation of interstitial glucose monitoring systems has contributed to improving glycemic control in recent years. Our objective was to know the metabolic control in people with type 1 DM and the Flash system and to establish if there is an association between its use and glycemic control variables.Mat...

Introduction and objectives: Diabetic ketoacidosis (DKA) is a severe acute complication of Diabetes Mellitus (DM) and as such, on a large number of occasions will require hospital admission. As we know, it happens when there is an absolute or relative insulin deficit, although it is true that the characteristics described in the literature of these episodes are very different. Our aim was to compare the characteristics of DKA occurring in patients under 25 years of age with th...

Objective: ACTH-secreting pituitary tumors (ACTHomas) express vasopressin (AVP) receptors. AVP receptors are also present in other types of cancer, exerting different effects on tumor growth depending on the receptor subtype. AVP type 1 receptors (V1a and V1b) are associated with stimulation of cell proliferation, AVP receptor type 2 (V2r) is associated with antiproliferative effects. Desmopressin (DAVP) is a synthetic analog of AVP that acts as a selective agonist for V2r, wh...

Background: Thyroid nodules are one of the most common clinical entities in Endocrinology practice. Fine needle aspiration (FNA) and the 2017 Bethesda System for Reporting Thyroid Cytopathology have been proved to be an effective tool to identify malignancy risk and guide surgical decision-making. However, thyroid nodules classified as Bethesda (BTH) III and IV remain a challenge, considering the varying risk of malignancy (ROM) found in different papers. The aim of this study...

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...